Yıl 2018, Cilt 18, Sayı 2, Sayfalar 198 - 206 2018-06-25

Metabolic Syndrome in Rheumatoid Arthritis and Ankylosing Spondylitis
Romatoid Artrit ve Ankilozan Spondilitli Hastalarda Metabolik Sendrom

Bilge Kesikburun [1] , Emel Ekşioğlu [2] , Aytül Çakcı [3]

106 166

Objectives: To evaluate and compare the prevalence of insulin resistance and metabolic syndrome (MetS) in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS) and to determine the relationship of MetS with disease-activities and the factors associated with MetS.

Materials and Methods: The cross-sectional study included a total of 174 patients with RA and AS. MetS was defined according to the International Diabetes Federation (IDF) criteria. Insulin resistance was assessed with the Homeostasis Model Assessment (HOMA) Index. The Disease Activity Score including 28 joints (DAS28) and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were used to measure disease activity. Functional status was evaluated using the Health Assessment Questionnaire (HAQ) and the Bath Ankylosing Spondylitis Functional Index (BASFI). Logistic regression analysis was applied to identify predictors of metabolic syndrome.

Results: The prevalence of MetS was significantly higher in patients with RA (47%) than in patients with AS (24.56%) (p=0.005). The prevalence of insulin resistance was significantly higher in patients with RA (34.18%) than in patients with AS (17.54%)(p=0.031). No significance difference was found in the disease activity score between RA and AS patients with metabolic syndrome and without metabolic syndrome (p=0.580 and p=0.158, respectively). The number of patients with a higher BASDAI score was greater in AS patients with MetS. Age and body mass index were determined to be predictors for MetS (p=0.015 and p<0.001, respectively).

Conclusion: Higher rates of MetS and insulin resistance were seen in RA patients compared to the patients with AS. Better control of the MetS components and disease activity may help to decrease the prevalence of MetS in rheumatic disease.

Amaç: Romatoid artrit (RA) ve ankilozan spondilitli (AS) hastalarda insülin direnci ve metabolik sendrom (MetS) prevalansını değerlendirmek ve karşılaştırmak, MetS’in hastalık aktivitesi ile ilişkisini ve MetS ile ilişkili faktörleri belirlemektir.

Materyal ve Metot: Kesitsel çalışma toplam 174 RA ve AS’li hasta içermektedir. MetS Uluslarası Diabet Federasyonu Kriterleri’ne (IDF) göre tanımlandı. İnsülin direnci Homeostas Model Assesment Index (HOMA) ile değerlendirildi. Hastalık aktivitesini ölçmek için 28 eklemi içeren hastalık aktivite skoru (DAS 28) ve Bath Ankilozan Spondilit Hastalık Aktivite İndeksi (BASDAI) kullanıldı. Fonksiyonel durumu Bath Ankilozan Spondilit Fonksiyonel İndeksi (BASFI) ve sağlık değerlendirme ölçeği (HAQ) kullanılarak değerlendirildi. MetS belirleyicilerini tanımlamak için çoklu regresyon analizi kullanıldı.

Bulgular: MetS prevalansı RA’lı hastalarda (%47) AS’li (%24,56) hastalardan daha yüksekti (p=0.005). İnsülin direnci prevalansı RA’lı hastalarda (%34,18) AS’li (%17,54) hastalardan daha yüksekti (p=0.031). MetS olan ve olmayan RA ve AS’li hastalar arasında hastalık aktivite skorları arasında anlamlı fark bulunmadı. (sırasıyla p=0,580 ve p=0,158). Yüksek BASDAI skorlarına sahip hasta sayısı MetS’li AS hastalarında daha yüksekti. Yaş ve vücut kitle indeksinin MetS için belirleyici olduğu saptandı (sırasıyla p=0,015 ve p<0,001).

Sonuç: AS’li hastalarla karşılaştırıldığında RA’lı hastalarda MetS ve insülin direnci yüksek oranda görüldü. MetS komponentlerinin ve hastalık aktivitesinin daha iyi kontrolü romatolojik hastalarda MetS prevalansının azalmasına yardımcı olabilir. 

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Birincil Dil en
Konular Sağlık Bilimleri
Dergi Bölümü Araştırmalar
Yazarlar

Yazar: Bilge Kesikburun (Sorumlu Yazar)

Yazar: Emel Ekşioğlu
Ülke: Turkey


Yazar: Aytül Çakcı
Ülke: Turkey


Bibtex @araştırma makalesi { amj435258, journal = {Ankara Medical Journal}, issn = {}, eissn = {2148-4570}, address = {Ankara Yıldırım Beyazıt Üniversitesi}, year = {2018}, volume = {18}, pages = {198 - 206}, doi = {10.17098/amj.435258}, title = {Metabolic Syndrome in Rheumatoid Arthritis and Ankylosing Spondylitis}, key = {cite}, author = {Ekşioğlu, Emel and Kesikburun, Bilge and Çakcı, Aytül} }
APA Kesikburun, B , Ekşioğlu, E , Çakcı, A . (2018). Metabolic Syndrome in Rheumatoid Arthritis and Ankylosing Spondylitis. Ankara Medical Journal, 18 (2), 198-206. DOI: 10.17098/amj.435258
MLA Kesikburun, B , Ekşioğlu, E , Çakcı, A . "Metabolic Syndrome in Rheumatoid Arthritis and Ankylosing Spondylitis". Ankara Medical Journal 18 (2018): 198-206 <http://www.ankaramedicaljournal.com/issue/37842/435258>
Chicago Kesikburun, B , Ekşioğlu, E , Çakcı, A . "Metabolic Syndrome in Rheumatoid Arthritis and Ankylosing Spondylitis". Ankara Medical Journal 18 (2018): 198-206
RIS TY - JOUR T1 - Metabolic Syndrome in Rheumatoid Arthritis and Ankylosing Spondylitis AU - Bilge Kesikburun , Emel Ekşioğlu , Aytül Çakcı Y1 - 2018 PY - 2018 N1 - doi: 10.17098/amj.435258 DO - 10.17098/amj.435258 T2 - Ankara Medical Journal JF - Journal JO - JOR SP - 198 EP - 206 VL - 18 IS - 2 SN - -2148-4570 M3 - doi: 10.17098/amj.435258 UR - http://dx.doi.org/10.17098/amj.435258 Y2 - 2018 ER -
EndNote %0 Ankara Medical Journal Metabolic Syndrome in Rheumatoid Arthritis and Ankylosing Spondylitis %A Bilge Kesikburun , Emel Ekşioğlu , Aytül Çakcı %T Metabolic Syndrome in Rheumatoid Arthritis and Ankylosing Spondylitis %D 2018 %J Ankara Medical Journal %P -2148-4570 %V 18 %N 2 %R doi: 10.17098/amj.435258 %U 10.17098/amj.435258
ISNAD Kesikburun, Bilge , Ekşioğlu, Emel , Çakcı, Aytül . "Romatoid Artrit ve Ankilozan Spondilitli Hastalarda Metabolik Sendrom". Ankara Medical Journal 18 / 2 (Haziran 2018): 198-206. http://dx.doi.org/10.17098/amj.435258