Year 2019, Volume 19, Issue 1, Pages 123 - 132 2019-03-22

Correlation of Liver Enzyme Levels and Insulin Resistance in Patients with Non-Alcoholic Steatosis
Non-Alkolik Steatoz Hastalarında Karaciğer Enzim Düzeylerinin ve İnsülin Direncinin Korelasyonu

Demet Cekdemir [1] , Mehmet Gunduz [2] , Arzu Celebi [3] , Hale Aslantas [4] , Gokhan Pekındıl [5] , Semin Ayhan [6] , Ender Ellidokuz [7]

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Objectives: To compare non-alcoholic steatosis patients according to liver enzyme levels, and to establish whether glucose metabolism and insulin resistance differ with liver enzyme levels.
Materials and Methods: Patients with non-alcoholic steatosis aged between 18-65 years were included in this study. The patients were divided into two groups as steatotic patients with normal liver enzymes (NLE), and those with increased liver enzymes (ILE). The groups were compared as for parameters of glucose metabolism, and insulin resistance.
Results: A total of 66 steatotic patients (40 NLE, and 26 ILE) were included in our study. Mean insulin values in the steatotic NLE, and ILE groups were 12.92±5.61, and 16.22±5.43 μU/mL respectively (p=0.012). Insulin resistance was detected in 23 (60.50%) patients in the steatotic NLE, and in 22 (88%) patients in the steatotic ILE groups (p=0.018). Metabolic syndrome was detected in 31 (77.50%) patients in the steatotic NLE, and in 15 (57.70%) patients in the steatotic ILE groups (p=0.058).
Conclusion: In conclusion, we have concluded that the steatotic group with ILE had higher insulin resistance. These patients should be meticulously taken into consideration as for drug treatments which will especially decrease insulin resistance, increase both weight loss, and sensitivity to insulin resistance. Liver biopsy still retains its essential place in definitive differential diagnosis.

Amaç: Non-alkolik basit hepatik steatoz hastalarını karaciğer enzim düzeylerine göre karşılaştırmak ve glikoz metabolizması ve insülin direncinin karaciğer enzim düzeyleri ile farklılık gösterip göstermediğini saptamak.

Materyal ve Metot: Çalışmaya 18-65 yaş arası non-alkolik basit hepatik steatozu olan hastalar dahil edildi. Hastalar normal karaciğer enzimleri (NKE) ve artmış karaciğer enzimleri (AKE) olan hastalar olarak iki gruba ayrıldı. Gruplar, glukoz metabolizması parametreleri ve insülin direnci açısından karşılaştırıldı.
Bulgular: Çalışmamıza toplam 66 steatotik hasta (40 NKE ve 26 AKE) dahil edildi. NKE ve AKE gruplarında ortalama insülin değerleri sırasıyla 12,92 ± 5,61 ve 16,22 ± 5,43 μU / mL idi (p = 0,012). NKE'deki 23 (%60,50) hastada ve steatotik AKE grubunda 22 hastada (%88) insülin direnci saptandı (p = 0,018). NKE'de 31 (%77,50) hastada ve AKE grubunda 15 hastada (%57,70) metabolik sendrom saptandı (p = 0,058).

Sonuç: Sonuç olarak, AKE'li steatotik grubun insülin direncinin daha yüksek olduğu sonucuna vardık. Bu hastalar özellikle insülin direncini azaltacak hem kilo kaybını artıracak hem de insülin direncine duyarlı olacak ilaç tedavileri konusunda titiz bir şekilde dikkate alınmalıdır. Karaciğer biyopsisi, kesin ayırıcı tanıda gerekli yerini hala korumaktadır.

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Primary Language en
Subjects Health Care Sciences and Services
Journal Section Research Articles
Authors

Author: Demet Cekdemir (Primary Author)

Author: Mehmet Gunduz

Author: Arzu Celebi

Author: Hale Aslantas

Author: Gokhan Pekındıl

Author: Semin Ayhan

Author: Ender Ellidokuz

Bibtex @research article { amj542200, journal = {Ankara Medical Journal}, issn = {}, eissn = {2148-4570}, address = {Ankara Yildirim Beyazit University}, year = {2019}, volume = {19}, pages = {123 - 132}, doi = {10.17098/amj.542200}, title = {Correlation of Liver Enzyme Levels and Insulin Resistance in Patients with Non-Alcoholic Steatosis}, key = {cite}, author = {Cekdemir, Demet and Gunduz, Mehmet and Celebi, Arzu and Aslantas, Hale and Pekındıl, Gokhan and Ayhan, Semin and Ellidokuz, Ender} }
APA Cekdemir, D , Gunduz, M , Celebi, A , Aslantas, H , Pekındıl, G , Ayhan, S , Ellidokuz, E . (2019). Correlation of Liver Enzyme Levels and Insulin Resistance in Patients with Non-Alcoholic Steatosis. Ankara Medical Journal, 19 (1), 123-132. DOI: 10.17098/amj.542200
MLA Cekdemir, D , Gunduz, M , Celebi, A , Aslantas, H , Pekındıl, G , Ayhan, S , Ellidokuz, E . "Correlation of Liver Enzyme Levels and Insulin Resistance in Patients with Non-Alcoholic Steatosis". Ankara Medical Journal 19 (2019): 123-132 <http://www.ankaramedicaljournal.com/issue/44012/542200>
Chicago Cekdemir, D , Gunduz, M , Celebi, A , Aslantas, H , Pekındıl, G , Ayhan, S , Ellidokuz, E . "Correlation of Liver Enzyme Levels and Insulin Resistance in Patients with Non-Alcoholic Steatosis". Ankara Medical Journal 19 (2019): 123-132
RIS TY - JOUR T1 - Correlation of Liver Enzyme Levels and Insulin Resistance in Patients with Non-Alcoholic Steatosis AU - Demet Cekdemir , Mehmet Gunduz , Arzu Celebi , Hale Aslantas , Gokhan Pekındıl , Semin Ayhan , Ender Ellidokuz Y1 - 2019 PY - 2019 N1 - doi: 10.17098/amj.542200 DO - 10.17098/amj.542200 T2 - Ankara Medical Journal JF - Journal JO - JOR SP - 123 EP - 132 VL - 19 IS - 1 SN - -2148-4570 M3 - doi: 10.17098/amj.542200 UR - https://doi.org/10.17098/amj.542200 Y2 - 2019 ER -
EndNote %0 Ankara Medical Journal Correlation of Liver Enzyme Levels and Insulin Resistance in Patients with Non-Alcoholic Steatosis %A Demet Cekdemir , Mehmet Gunduz , Arzu Celebi , Hale Aslantas , Gokhan Pekındıl , Semin Ayhan , Ender Ellidokuz %T Correlation of Liver Enzyme Levels and Insulin Resistance in Patients with Non-Alcoholic Steatosis %D 2019 %J Ankara Medical Journal %P -2148-4570 %V 19 %N 1 %R doi: 10.17098/amj.542200 %U 10.17098/amj.542200
ISNAD Cekdemir, Demet , Gunduz, Mehmet , Celebi, Arzu , Aslantas, Hale , Pekındıl, Gokhan , Ayhan, Semin , Ellidokuz, Ender . "Correlation of Liver Enzyme Levels and Insulin Resistance in Patients with Non-Alcoholic Steatosis". Ankara Medical Journal 19 / 1 (March 2019): 123-132. https://doi.org/10.17098/amj.542200