Year 2019, Volume 19, Issue 1, Pages 115 - 122 2019-03-22

Urinary Tract Infections in Neonatal Intensive Care Unit: 4-Year Experience
Yenidoğan Yoğun Bakım Ünitesinde İdrar Yolu Enfeksiyonları: 4 Yıllık Deneyim

Sara Erol [1] , Nilgün Altuntaş [2]

15 77

Objectives: Urinary tract infection in neonatal period is an important cause of late sepsis for term and preterm infants. The aim of this study was to evaluate the results of clinical, laboratory and radiological examinations of patients admitted to the third-level neonatal intensive care unit with urinary tract infection.

Materials and Methods: The results of clinical, laboratory and radiological imaging of term newborns who were diagnosed as urinary tract infection according to urine culture obtained by bladder catheterization and accepted into neonatal intensive care unit were obtained from computer records retrospectively. Differences and relationships of the data were statistically evaluated.

Results: The data of 43 patients who were followed up in the neonatal intensive care unit with the diagnosis of urinary tract infection between 2015-2018 were evaluated. 77 (n=30) % of the cases were male and the diagnosis day was median 10 (7-28 days). 22 (51%) of the cases presented with jaundice, 6 (13.96%) with vomiting, 5 (11.62%) with fever and 4 (9.30%) with feeding difficulties and 13.96% had no symptoms at admission. The most common microorganisms were Escherichia coli (60.46%) and Klebsiella pneumonia (20.93%). Amikacin resistance was significantly lower in patients with Escherichia coli and Klebsiella pneumonia compared to gentamicin resistance (p<0.001 and p = 0.046).

Conclusion: Neonatal urinary tract infections can be clinically asymptomatic or cause sepsis and renal damage and may be a major cause of morbidity and mortality. The initiation of empirical antibiotic therapy according to variable antibiotic resistance is as important as the clinical and laboratory findings for early and effective treatment.

Amaç: Yenidoğan döneminde idrar yolu enfeksiyonu, term ve preterm bebekler için önemli bir geç sepsis nedenidir. Bu çalışmanın amacı üçüncü düzey bir yenidoğan yoğun bakım ünitesine idrar yolu enfeksiyonu tanısıyla kabul edilen hastaların klinik, laboratuvar ve radyolojik inceleme sonuçlarını değerlendirmektir.

Materyal ve Metot: Mesane kateterizasyonu ile alınan idrar kültürüne göre idrar yolu enfeksiyonu tanısı alan ve yenidoğan yoğun bakım ünitesine kabul edilen term yenidoğanlara ait klinik, laboratuvar ve radyolojik görüntüleme sonuçlarına geriye dönük olarak bilgisayar kayıtlarından ulaşıldı. Verilerin farklılıkları ve ilişkileri istatistiksel olarak değerlendirildi.

Bulgular: 2015-2018 yılları arasında idrar yolu enfeksiyonu tanısıyla yenidoğan yoğun bakımda izlenen 43 hastanın verileri değerlendirildi. Olguların %77 (n=30)’si erkekti ve ortalama tanı günü median 10 (7-28 gün) olarak bulundu. Olguların 22(%51,16)’si sarılık, 6(%13,96)’sı kusma, 5(%11,62)’i ateş, 4(%9,30)’ü beslenme güçlüğü yakınmaları ile başvururken %13,96’sının başvuru sırasında semptomu yoktu. En sık üreyen mikroorganizmalar %60,46 oranında Escherichia coli ve %20,93 oranında Klebsiella pneumonia idi. Amikasin direncinin Escherichia coli ve Klebsiella pneumonia üreyen hastalarda gentamisin direncine göre anlamlı şekilde düşük olduğu görüldü (sırasıyla p<0,001 ve p=0,046).

Sonuç: Neonatal idrar yolu enfeksiyonları klinik olarak asemptomatik olabilecekleri gibi sepsis ve renal hasara yol açarak önemli morbidite ve mortalite nedeni de olabilirler. Erken ve etkin tedavi için klinik ve laboratuvar bulguların değerlendirilmesi kadar, değişken antibiyotik dirençlerinin dikkate alınarak ampirik antibiyotik tedavisinin başlanması önemlidir. 

  • Bonadio W, Maida G. Urinary tract infection in outpatient febrile infants younger than 30 days of age: a 10-year evaluation. Pediatr Infect Dis J. 2014;33(4):342-4. Levy I, Comarsca J, Davidovits M, Klinger G, Sirota L, Linder N. Urinary tract infection in preterm infants: the protective role of breastfeeding. Pediatr Nephrol 2009;24:527–31.
  • Riskin A, Toropine A, Bader D, Hemo M, Srugo I, Kugelman A. Is it justified to include urine cultures in early (< 72 hours) neonatal sepsis evaluations of term and late preterm infants? Am J Perinatol. 2013;30(6):499-504.
  • Ismaili K, Lolin K, Damry N, Alexander M, Lepage P, Hall M. Febrile urinary tract infections in 0- to 3-month-old infants: a prospective follow-up study. J Pediatr. 2011;158(1):91-4.
  • Eliakim A, Dolfin T, Korzets Z, Wolach B, Pomeranz A. Urinary tract infection in premature infants: the role of imaging studies and prophylactic therapy. J Perinatol. 1997;17(4):305-8.
  • Wiswell TE, Geschke DW. Risks from circumcision during the first month of life compared with those for uncircumcised boys. Pediatrics. 1989;83(6):1011-5.
  • Sastre JB1, Aparicio AR, Cotallo GD, Colomer BF, Hernández MC; Grupo de Hospitales Castrillo. Urinary tract infection in the newborn: clinical and radio imaging studies. Pediatr Nephrol. 2007;22(10):1735-41.
  • Wallace SS, Zhang W, Mahmood NF et al. Renal Ultrasound for Infants Younger Than 2 Months With a Febrile Urinary Tract Infection. AJR Am J Roentgenol. 2015;205(4):894-8.
  • Arshad M, Seed PC. Urinary tract infections in the infant. Clin Perinatol. 2015;42(1):17-28.
  • Garcia FJ, Nager AL. Jaundice as an early diagnostic sign of urinary tract infection in infancy. Pediatrics. 2002;109(5):846-51.
  • Shahian M1, Rashtian P, Kalani M. Unexplained neonatal jaundice as an early diagnostic sign of urinary tract infection. Int J Infect Dis. 2012;16(7):487-90
  • Maherzi M, Guignard JP, Torrado A. Urinary tract infection in high-risk newborn infants. Pediatrics. 1978;62(4):521-3.
  • Bergström T, Larson H, Lincoln K, Winberg J. Studies of urinary tract infections in infancy and childhood. XII. Eighty consecutive patients with neonatal infection. J Pediatr. 1972;80(5):858-66.
  • Tzimenatos L, Mahajan P, Dayan PS et al. Pediatric Emergency Care Applied Research Network (PECARN). Accuracy of the Urinalysis for Urinary Tract Infections in Febrile Infants 60 Days and Younger. Pediatrics. 2018;141(2). pii: e20173068.
  • Downs SM. Technical report: urinary tract infections in febrile infants and young children. The Urinary Tract Subcommittee of the American Academy of Pediatrics Committee on Quality Improvement. Pediatrics. 1999;103(4):e54.
  • Altuntas N, Tayfur AC, Kocak M, Razi HC, Akkurt S. Midstream clean-catch urine collection in newborns: a randomized controlled study. Eur J Pediatr. 2015;174(5):577-82.
  • Herreros Fernández ML, González Merino N, Tagarro García A et al. A new technique for fast and safe collection of urine in newborns. Arch Dis Child. 2013 Jan;98(1):27-9. doi: 10.1136/archdischild-2012-301872. Epub 2012 Nov 21.
  • Downey LC, Benjamin DK Jr, Clark RH et al. Urinary tract infection concordance with positive blood and cerebrospinal fluid cultures in the neonatal intensive care unit. J Perinatol. 2013;33(4):302-6.
  • Yam AO, Andresen D, Kesson AM, Isaacs D. Incidence of sterile cerebrospinal fluid pleocytosis in infants with urinary tract infection.nJ Paediatr Child Health. 2009 Jun;45(6):364-7.
  • Wallace SS, Brown DN, Cruz AT. Prevalence of Concomitant Acute Bacterial Meningitis in Neonates with Febrile Urinary Tract Infection: A Retrospective Cross-Sectional Study. J Pediatr. 2017;184:199-203.
  • Parkkinen J, Virkola R, Korhonen TK. Identification of factors in human urine that inhibit the binding of Escherichia coli adhesins. Infect Immun. 1988;56(10):2623-30.
  • Pauchard JY1, Chehade H2, Kies CZ1, Girardin E3, Cachat F2, Gehri M1. Avoidance of voiding cystourethrography in infants younger than 3 months with Escherichia coli urinary tract infection and normal renal ultrasound. Arch Dis Child. 2017;102(9):804-8
  • Beetz R. Evaluation and management of urinary tract infections in the neonate. Curr Opin Pediatr. 2012;24(2):205-11.
Primary Language tr
Subjects Health Care Sciences and Services
Journal Section Research Articles
Authors

Author: Sara Erol (Primary Author)

Author: Nilgün Altuntaş

Bibtex @research article { amj542422, journal = {Ankara Medical Journal}, issn = {}, eissn = {2148-4570}, address = {Ankara Yildirim Beyazit University}, year = {2019}, volume = {19}, pages = {115 - 122}, doi = {10.17098/amj.542422}, title = {Yenidoğan Yoğun Bakım Ünitesinde İdrar Yolu Enfeksiyonları: 4 Yıllık Deneyim}, key = {cite}, author = {Erol, Sara and Altuntaş, Nilgün} }
APA Erol, S , Altuntaş, N . (2019). Yenidoğan Yoğun Bakım Ünitesinde İdrar Yolu Enfeksiyonları: 4 Yıllık Deneyim. Ankara Medical Journal, 19 (1), 115-122. DOI: 10.17098/amj.542422
MLA Erol, S , Altuntaş, N . "Yenidoğan Yoğun Bakım Ünitesinde İdrar Yolu Enfeksiyonları: 4 Yıllık Deneyim". Ankara Medical Journal 19 (2019): 115-122 <http://www.ankaramedicaljournal.com/issue/44012/542422>
Chicago Erol, S , Altuntaş, N . "Yenidoğan Yoğun Bakım Ünitesinde İdrar Yolu Enfeksiyonları: 4 Yıllık Deneyim". Ankara Medical Journal 19 (2019): 115-122
RIS TY - JOUR T1 - Yenidoğan Yoğun Bakım Ünitesinde İdrar Yolu Enfeksiyonları: 4 Yıllık Deneyim AU - Sara Erol , Nilgün Altuntaş Y1 - 2019 PY - 2019 N1 - doi: 10.17098/amj.542422 DO - 10.17098/amj.542422 T2 - Ankara Medical Journal JF - Journal JO - JOR SP - 115 EP - 122 VL - 19 IS - 1 SN - -2148-4570 M3 - doi: 10.17098/amj.542422 UR - https://doi.org/10.17098/amj.542422 Y2 - 2019 ER -
EndNote %0 Ankara Medical Journal Yenidoğan Yoğun Bakım Ünitesinde İdrar Yolu Enfeksiyonları: 4 Yıllık Deneyim %A Sara Erol , Nilgün Altuntaş %T Yenidoğan Yoğun Bakım Ünitesinde İdrar Yolu Enfeksiyonları: 4 Yıllık Deneyim %D 2019 %J Ankara Medical Journal %P -2148-4570 %V 19 %N 1 %R doi: 10.17098/amj.542422 %U 10.17098/amj.542422
ISNAD Erol, Sara , Altuntaş, Nilgün . "Yenidoğan Yoğun Bakım Ünitesinde İdrar Yolu Enfeksiyonları: 4 Yıllık Deneyim". Ankara Medical Journal 19 / 1 (March 2019): 115-122. https://doi.org/10.17098/amj.542422